Tuesday, November 22, 2011

Something Fishy for Fighters....

This fascinating scientific tidbit below comes from my good friend at High Performance Nutrition

I have previously discussed here on the Combat Sport Psychology site, some of the hazards associated with recurrent concussions (see "Watch Your Head"), a phenomenon not at all uncommon among amateur and professional combat sport athletes (and among drunks, the ill-tempered, and those whose mouths regularly write checks that their other ends' cannot cash) .  Here - however- is some potential good news.  (RB)

Fighters may be able to reduce their risk of developing brain damage by taking fish oil supplements. According to an animal study by American neurologists, brain cells recover more quickly from head trauma when given DHA, a fatty acid in fish oil.

The researchers, working at West Virginia University, wanted to know whether the brains of people with head injuries recovered more quickly or better when given fish oil supplements. The brain contains relatively high amounts of DHA, the fatty acid found in fish oil. This substance stimulates the growth of brain cells and protects them against damage and stress too.

The researchers gave a group of rats concussion of the same degree and then let the animals recuperate for 30 days. Some of the rats were given a standard diet, some were given 10 mg DHA per kg bodyweight daily, and yet another group were given 40 mg DHA per kg bodyweight per day on top of their standard food.

At the end of the 30 days the researchers examined the rats' brain cells. They were looking for precursors of beta-amyloid precursor protein [APP] in the axons, the long protrusions at the end of nerve cells. Beta-amyloid peptides form plaques in the brains of people who have Alzheimer's or dementia, but they probably also do this in the brains of people who have received severe blows to the head.

Sham = rats not given concussion.

If cells become so damaged that they cannot repair themselves, they kill themselves. When this happens, the synthesis of the suicide enzyme caspase-3 rises. This is what happened in the brain cells of the rats that had been given a blow – but it happened considerably less in the rats that had been given DHA.

If you convert the doses used into the amount needed for a human weighing 100 kg [for the sake of easy maths] and take into account the fact that humans' metabolism is slower than that of rats, you arrive at a dose of somewhere between 100 and 400 mg per day. Most of the cheap kinds of fish oil contain 10-15 percent of DHA. That means you need to take 1-4 of the big one-gram capsules a day.

It's not clear whether other omega-3 fatty acids work as well as DHA, but of all the omega-3 fatty acid molecules in the brain, 97 percent of them are DHA.

J Neurotrauma. 2010 Sep; 27(9): 1617-24.